Reaction: G beta-gamma complex and PIP3 recruit BTK to membrane
- in pathway: G beta:gamma signalling through BTK
G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins (G-proteins) that have alpha, beta and gamma subunits. Upon activation, the alpha subunit of G-proteins dissociates from beta-gamma and the both are then free to regulate downstream effectors. G-protein beta-gamma complex, along with phosphatidylinositol 3,4,5-trisphosphate (PIP3), recruits the non-receptor Tyrosine-protein kinase BTK to the cell membrane. This recruitment involves binding of the G-protein beta-gamma complex to the pleckstrin homology/Tec-homology module of Btk. Here, BTK is activated and subsequently released to the cytoplasm. Physiologically, BTK plays a key role in B lymphocyte development, differentiation and signalling.
Reaction - small molecule participants:
PI(3,4,5)P3 [plasma membrane]
Reactome.org reaction link: R-HSA-8964241
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Reaction input - small molecules:
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
Reaction output - small molecules:
Reactome.org link: R-HSA-8964241