Reaction: G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC
- in pathway: G alpha (i) signalling events
G-Protein Coupled Receptors sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the alpha subunit of the G protein (GNAI) can directly bind to SRC. In the presence of active GNAI, SRC can autophosphorylate the 419-tyrosine residue, which leads to the subsequent activation of SRC. Physiologically, the SRC family have implications in cell growth and cancer.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-8964242
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-8964242