Reaction: PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex
- in pathway: G beta:gamma signalling through BTK
G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins (G-proteins) that have alpha, beta and gamma subunits. Upon activation, the alpha subunit of G-proteins dissociates from beta-gamma and the both are then free to regulate downstream effectors. G-protein beta-gamma complex, along with phosphatidylinositol 3,4,5-trisphosphate (PIP3), recruits the non-receptor Tyrosine-protein kinase BTK to the cell membrane. Here, the G-protein beta-gamma complex activates BTK. Once active, BTK dissociates from PIP3 and G-protein beta-gamma complex and is released to the cytoplasm to phosphorylate downstream substrates. Physiologically, BTK plays a key role in B lymphocyte development, differentiation and signalling.
Reaction - small molecule participants:
PI(3,4,5)P3 [plasma membrane]
Reactome.org reaction link: R-HSA-8964317
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Reaction input - small molecules:
Reaction output - small molecules:
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
Reactome.org link: R-HSA-8964317