Reaction: G alpha (z) in G alpha (z):RGS complex is inactivated
- in pathway: G alpha (z) signalling events
G Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins (G proteins). Upon activation, GPCRs can replace the GDP with GTP in the alpha subunit of G proteins. GTP binding modifies the conformation of G alpha proteins and activates them. The Regulator of G protein Signalling (RGS) are GTPase Accelerating Proteins (GAPs) that can directly inhibit the G alpha subunit activity. There are at least 25 different types of RGS proteins known. RGS16, RGS17 and RGS20 can bind and stabilize the transition state of Guanine nucleotide binding protein G(z) subunit alpha (GNAZ). Following this, RGS exerts its GAP activity on GNAZ and facilitates the hydrolyses GTP to GDP. This inactivates GNAZ and terminates downstream signalling (Neubig & Siderovski 2002, Kach et al. 2012, Goto K et al. 2017). GNAZ inhibits adenylyl cyclase and interacts with Rap1GAP to attenuate Rap1 signaling.
Reaction - small molecule participants:
Pi [cytosol]
Reactome.org reaction link: R-HSA-8982021
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Reaction input - small molecules:
Reaction output - small molecules:
hydrogenphosphate
Reactome.org link: R-HSA-8982021