Reaction: PGM2:Mg2+ isomerises dR1P to dR5P
- in pathway: Pentose phosphate pathway
The nucleoside breakdown product deoxyribose-1-phosphate (dR1P) can be used to produce energy during oxidative or mitochondrial stress to minimize or delay stress-induced damage. Two steps connect this nucleoside breakdown product to central carbon metabolism in mammals. In the first step, dR1P is isomerised to the corresponding 5-phosphopentose, dR5P, mediated by phosphoglucomutase-2 (PGM2). PGM2 is a cytosolic, M2+-dependent enzyme that acts ten times better as a phosphopentomutase (both on R1P and dR1P) than as a phosphoglucomutase (on glucose-1-phosphate) (Maliekal et al. 2007).
Reaction - small molecule participants:
dR5P [cytosol]
dR1P [cytosol]
Reactome.org reaction link: R-HSA-8982667
======
Reaction input - small molecules:
2-deoxy-alpha-D-ribose 1-phosphate(2-)
Reaction output - small molecules:
2-deoxy-D-ribose 5-phosphate(2-)
Reactome.org link: R-HSA-8982667