Reaction: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4
- in pathway: Interleukin-35 Signalling
Interleukin 35 (IL35) binding activates the IL35 receptor complex and may facilitate Tyrosine protein kinase JAK (JAK) phosphorylation. Subsequently, Signal transducer and activator of transcription 4 alpha/beta (STAT4) may bind to the receptor complex and is activated by tyrosine phosphorylation (Collison et al. 2012). JAK2 is known to be involved in the phosphorylation of STAT1 (Higashi T et al., 2005).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-8983872
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-8983872