Reaction: OAS2 produces oligoadenylates
- in pathway: OAS antiviral response
2'-5'-oligoadenylate synthetase 2 (OAS2) polymerizes ATP into 5'-triphosphorylated, 2'-5'-linked oligoadenylate (2-5A) (Hovanessian AG et al. 1988; Sarkar SN et al. 1999, 2002). 2-5A molecules are recognized by ribonuclease L (RNase L) (Han Y et al. 2014; Huang H et al. 2014). Activated RNase L cleaves viral and cellular RNA resulting in the inhibition of viral replication (Silverman RH 2007).
Reaction - small molecule participants:
PPi [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-8985104
======
Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
diphosphate(3-)
Reactome.org link: R-HSA-8985104