Reaction: IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3
- in pathway: Interleukin-9 signaling
Tyrosine-protein kinase JAK3 (JAK3) is believed to become phosphorylated after IL9:IL9R interaction as this is thought to be a mechanism common to all receptors that incorporate IL2RG (Haan et al. 2011). There is no clear evidence for JAK1 phosphorylation by IL9 treatment, except in pathological states (Hornakova et al. 2009, Gordon et al. 2010).
This is a black box event because phosphorylation of JAK3 is inferred from the signaling mechanism of the related IL2 receptor (Johnston et al. 1994).
This is a black box event because phosphorylation of JAK3 is inferred from the signaling mechanism of the related IL2 receptor (Johnston et al. 1994).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-8985914
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-8985914