Reaction: IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5
- in pathway: Interleukin-20 family signaling
IFNL1 can induce phosphorylation of Signal transducer and activator of transcription 1 alpha/beta (STAT1), Signal transducer and activator of transcription 3 (STAT2), Signal transducer and activator of transcription 3 (STAT3), Signal transducer and activator of transcription 4 (STAT4) and Signal transducer and activator of transcription 5 (STAT5) (Dumoutier et al. 2004, Novak et al. 2008, Dickensheets et al. 2013) via stimulation of the Interferon lambda-1 (IFNL1) receptor complex. This complex consists of IFNL1, IFNLR1, which is associated with phosphorylated Tyrosine-protein kinase JAK1 (JAK1), Interleukin-10 receptor beta (IL10RB), which is associated with phosphorylated Non-receptor tyrosine-protein kinase TYK2 (TYK2) and STAT1.
This is a black-box event because direct evidence for STAT4 and 5 binding and activation is lacking (Jordan et al. 2007).
This is a black-box event because direct evidence for STAT4 and 5 binding and activation is lacking (Jordan et al. 2007).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-8986985
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-8986985