Reaction: IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA
- in pathway: Interleukin-20 family signaling
Interleukin-22 receptor subunit alpha-1 (IL22RA1) is phosphorylated within the receptor complex, which consists of Interleukin-22 (IL22), IL22RA1 associated with phosphorylated Tyrosine protein kinase JAK1 (JAK1) and Interleukin-10 receptor subunit beta (IL10RB) associated with phosphorylated non-receptor tyrosine-protein kinase TYK2 (TYK2). IL22 stimulated IL22RA1 tyrosine phosphorylation and recruitment of Tyrosine protein phosphatase non receptor type 11 (PTPN11, SHP2). PTPN11 binding was abolished by mutation of Tyrosines-251 and 301 (Meng et al. 2010).
This is a black-box event because it is not clear which kinase is responsible for IL22RA1 phosphorylation.
This is a black-box event because it is not clear which kinase is responsible for IL22RA1 phosphorylation.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-8986995
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-8986995