Reaction: IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2
- in pathway: Interleukin-20 family signaling
Inferred from rat, mouse, human :Tyrosine protein kinase JAK1 (JAK1) and Non-receptor tyrosine-protein kinase TYK2 (TYK2) are believed to be phosphorylated after Interleukin-22 interacts with its receptor. The receptor is a complex formed by Interleukin-22 receptor subunit alpha-1 (IL22RA1), JAK1, Interleukin-10 receptor subunit beta (IL10RB) and TYK2 (Lejeune et al. 2002, Sabat et al. 2014).
This is a black-box event because the JAK1/TYK2 coordinates phosphorylated after IL22 stimulus are unknown.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-8987042
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-8987042