Reaction: IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3
- in pathway: Interleukin-20 family signaling
Signal transducer and activator of transcription 3 (STAT3) is phosphorylated after binding to Interleukin-24 (IL24) activated receptor complex. This activated receptor complex is formed by IL24 ligand, Interleukin-22 receptor subunit alpha-1 (IL22RA1), phosphorylated Tyrosine-protein kinase JAK1 (JAK1) and Interleukin-20 receptor subunit beta (IL20RB) (Parrish-Novak et al. 2002, Wang et al. 2002, Dumoutier et al. 2001).
This is a black box event since the identity of the phosphorylated residues in STAT3 is unknown.
This is a black box event since the identity of the phosphorylated residues in STAT3 is unknown.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-8987096
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-8987096