Reaction: GSK3B phosphorylates RUNX2
- in pathway: Regulation of RUNX2 expression and activity
GSK3B phosphorylates RUNX2 on three serine residues in an evolutionarily conserved motif SPPWSYDQS, which decreases the DNA binding ability of RUNX2 (Kugimiya et al. 2007, Kumar et al. 2015).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-9008480
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9008480