Reaction: TBK1 phosphorylation
- in pathway: Interleukin-37 signaling
Serine/threonine protein kinase TBK1 plays a key role in regulating inflammatory responses. TBK1 activity is regulated by phosphorylation of Ser 172 within the kinase activation loop (Kishore et al. 2002). TBK1 phosphorylation is thought to be an autoactivation event. The IL 37b:IL-18R1:SIGIRR complex can suppress TBK1 activity (Nold Petry et al. 2015, Clark K et al. 2009). This event is set as a black box event instance because the precise mechanism of TBK1 suppression by IL 37b:IL-18R1:SIGIRR complex is uncertain.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9008684
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9008684