Reaction: PPM1D dephosphorylates RUNX2
- in pathway: Transcriptional regulation by RUNX2
PPM1D (Wip1), a serine/threonine phosphatase, dephosphorylates RUNX2 on serine residue S432. Since it has not been tested whether S432 affects bindng of RUNX2 to CBFB, PPM1D is shown to dephosphorylate RUNX2 in the context of its complex with CBFB. The kinase responsible for RUNX2 phosphorylation at S432 is not known. PPM1D-mediated dephosphorylation of RUNX2 promotes RUNX2-mediated transcriptional activation of BAX and may play an important role in inducing apoptosis in TP53 negative tumor cells (Goloudina, Tanoue et al. 2012, Goloudina, Mazur et al. 2012).
Reaction - small molecule participants:
PPi [nucleoplasm]
H2O [nucleoplasm]
Reactome.org reaction link: R-HSA-9008822
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Reaction input - small molecules:
water
Reaction output - small molecules:
diphosphate(3-)
Reactome.org link: R-HSA-9008822