Reaction: STAT3 phosphorylation
- in pathway: Interleukin-37 signaling
Signal transducer and activator of transcription 3 (STAT3) acts downstream of various cellular receptors and is primarily involved in gene transcription. STAT3 is activated by serine/threonine kinases (Rebe et al. 2013). The IL-37:IL-18R1:SIGIRR complex can facilitate the phosphorylation and activation of STAT3 (Nold Petry et al. 2015). However, the precise mechanism is unclear. Hence, this event is represented as a black box.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9009072
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9009072