Reaction: MAN1B1 hydrolyses 1,2-linked mannose (c branch)
- in pathway: ER Quality Control Compartment (ERQC)
The enzyme ER Man I can slowly trim up to four of the mannoses on the N-glycan on unfolded proteins accumulated in the ER. This step describes the removal of the mannose in the C position (Gonzalez et al. 1999, Karaveg et al. 2005, Avezov et al. 2008).
Reaction - small molecule participants:
Man [endoplasmic reticulum quality control compartment]
H2O [endoplasmic reticulum quality control compartment]
Reactome.org reaction link: R-HSA-901039
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Reaction input - small molecules:
water
Reaction output - small molecules:
D-mannopyranose
Reactome.org link: R-HSA-901039