Reaction: VDAC1 transports PYR from cytosol to mitochondrial intermembrane space
- in pathway: Pyruvate metabolism
Similar to other ions and metabolites, pyruvate (PYR) probably crosses the outer mitochondrial membrane through the relatively non-specific, voltage-dependent anion-selective channel protein 1 (VDAC1) (McCommis & Finck 2015). Humans with defective VDAC1 show impaired PYR oxidation and ATP production (Huizing et al. 1996).
Reaction - small molecule participants:
PYR [mitochondrial intermembrane space]
PYR [cytosol]
Reactome.org reaction link: R-HSA-9012374
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Reaction input - small molecules:
pyruvate
Reaction output - small molecules:
pyruvate
Reactome.org link: R-HSA-9012374