Meta-Biol

• Pathways

The following GTPase activating proteins (GAPs) were shown to bind RHOB and stimulate its GTPase activity, resulting in GTP to GDP hydrolysis and conversion of the active RHOB:GTP complex into the inactive RHOB:GDP complex (the high throughput study by Bagci et al. 2020 examined binding to the active RHOB mutant but not activation of RHOB GTPase activity):
ABR (Amin et al. 2016, supported by Bagci et al. 2020)
ARHGAP1 (Amin et al. 2016, supported by Bagci et al. 2020)
ARHGAP5 (Kusama et al. 2006, supported by Bagci et al. 2020)
ARHGAP26 (Amin et al. 2016)
DLC1 (Healy et al. 2008, Amin et al. 2016)
MYO9B (Graf et al. 2000, supported by Bagci et al. 2020)
STARD13 (Amin et al. 2016)

The following GAPs were shown to bind RHOB and stimulate its GTPase activity in some but not all studies or have only been shown to bind to the active RHOB (as indicated) and are annotated as candidate RHOB GAPs:
ARHGAP21 (Bagci et al. 2020: binds to active RHOB)
ARHGAP32 (Bagci et al. 2020: binds to active RHOB)
ARHGAP35 (RHOB directed GAP activity: Amin et al. 2016; Bagci et al. 2020: no binding to active RHOB)
ARHGAP39 (Bagci et al. 2020: binds to active RHOB)
BCR (Bagci et al. 2020: binds to active RHOB)
DEPDC1B (Bagci et al. 2020: binds to active RHOB)
MYO9A (Bagci et al. 2020: binds to active RHOB)
OPHN1 (RHOB directed GAP activity: Amin et al. 2016; Bagci et al. 2020: no binding to active RHOB)
PIK3R1 (Bagci et al. 2020: binds to active RHOB)
PIK3R2 (Bagci et al. 2020: binds to active RHOB)
RACGAP1 (RHOB directed GAP activity: Amin et al. 2016; Bagci et al. 2020: no binding to active RHOB)
STARD8 (RHOB directed GAP activity: Braun et al. 2015; no RHOB directed GAP activity: Amin et al. 2016)

The following GAPs do not act on RHOB or were shown to not bind to the active RHOB, without testing for the ability to activate RHOB GTPase activity (as indicated):
ARAP2 (Bagci et al. 2020: does not bind active RHOB)
ARAP3 (Bagci et al. 2020: does not bind active RHOB)
ARHGAP12 (Bagci et al. 2020: does not bind active RHOB)
ARHGAP17 (Amin et al. 2016; Bagci et al. 2020: does not bind active RHOB)
ARHGAP29 (Bagci et al. 2020: does not bind active RHOB)
ARHGAP31 (Bagci et al. 2020: does not bind active RHOB)
ARHGAP42 (Bagci et al. 2020: does not bind active RHOB)
SRGAP2 (Bagci et al. 2020: does not bind active RHOB)
SYDE1 (Bagci et al. 2020: does not bind active RHOB)