Meta-Biol

• Pathways

The following GTPase activating proteins (GAPs) were shown to bind RHOC and stimulate its GTPase activity, resulting in GTP to GDP hydrolysis and conversion of the active RHOC:GTP complex into the inactive RHOC:GDP complex, or they were shown to bind to the constitutively active RHOC mutant in the high throughput screen conducted by Bagci et al. 2020, without testing for activation of RHOC GTPase activity (as indicated):
ARHGAP1 (Amin et al. 2016; supported by Bagci et al. 2020)
ARHGAP5 (Kusama et al. 2006; supported by Bagci et al. 2020)
ARHGAP18 (Chang et al. 2014)
ARHGAP26 (Amin et al. 2016)
DLC1 (Healy et al. 2008; Amin et al. 2016)
MYO9B (Graf et al. 2000; supported by Bagci et al. 2020)
RACGAP1 (Amin et al. 2016; supported by Bagci et al. 2020)
STARD13 (Amin et al. 2016)

The following GAPs were shown to bind RHOC and stimulate its GTPase activity in some but not all studies, or only their binding to the constitutively active RHOC mutant was shown without testing for activation of RHOC GTPase activity, and they are annotated as candidate RHOC GAPs:
ABR (Amin et al. 2016: RHOC directed GAP activity; Bagci et al. 2020: no binding to active RHOC)
ARHGAP21 (Lazarini et al. 2013: RHOC directed GAP activity; Bagci et al. 2020: no binding to active RHOC)
ARHGAP32 (Bagci et al. 2020: binding to active RHOC)
ARHGAP35 (Amin et al. 2016: RHOC directed GAP activity; Bagci et al. 2020: no binding to active RHOC)
ARHGAP39 (Bagci et al. 2020: binding to active RHOC)
BCR (Bagci et al. 2020: binding to active RHOC)
DEPDC1B (Bagci et al. 2020: binding to active RHOC)
OPHN1 (Amin et al. 2016: RHOC directed GAP activity; Bagci et al. 2020: no binding to active RHOC)
PIK3R1 (Bagci et al. 2020: binding to active RHOC)

The following GAPs do not act on RHOC or do not bind to the constitutively active RHOC mutant:
ARAP2 (Yoon et al. 2006; Bagci et al. 2020: no binding to active RHOC)
ARAP3 (Bagci et al. 2020: no binding to active RHOC)
ARHGAP12 (Bagci et al. 2020: no binding to active RHOC)
ARHGAP17 (Amin et al. 2016; Bagci et al. 2020: no binding to active RHOC)
ARHGAP29 (Bagci et al. 2020: no binding to active RHOC)
ARHGAP31 (Bagci et al. 2020: no binding to active RHOC)
ARHGAP42 (Bagci et al. 2020: no binding to active RHOC)
MYO9A (Bagci et al. 2020: no binding to active RHOC)
OCRL (Erdmann et al. 2006;Lichter Konecki et al. 2006; Bagci et al. 2020: no binding to active RHOC)
PIK3R2 (Bagci et al. 2020: no binding to active RHOC)
SRGAP2 (Bagci et al. 2020: no binding to active RHOC)
STARD8 (Amin et al. 2016)
SYDE1 (Bagci et al. 2020: no binding to active RHOC)