Meta-Biol

• Pathways

The following GTPase activating proteins (GAPs) were shown to bind RHOD and stimulate its GTPase activity, resulting in GTP to GDP hydrolysis and conversion of the active RHOD:GTP complex to the inactive RHOD:GDP complex (the study by Bagci et al. 2020 is cited as supporting evidence since it only examined binding of GAPs to active RHOD without testing for RHOD-directed GAP activity):
ARHGAP1 (Amin et al. 2016; supported by Bagci et al. 2020)
ARHGAP26 (Amin et al. 2016)
ARHGAP32 (Paul et al. 2017; supported by Bagci et al. 2020)
ARHGAP35 (Amin et al. 2016; supported by Bagci et al. 2020)

The following GAPs were shown to bind RHOD and stimulate its GTPase activity in some but not all studies or were shown by Bagci et al. 2020 to bind to active RHOD without testing for RHOD-directed GAP activity and are annotated as candidate RHOD GAPs:
ARHGAP5 (Bagci et al. 2020)
ARHGAP12 (Bagci et al. 2020)
ARHGAP17 (Amin et al. 2016: RHOD directed GAP activity; Bagci et al. 2020: no binding to active RHOD)
ARHGAP21 (Bagci et al. 2020)
ARHGAP39 (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
PIK3R1 (Bagci et al. 2020)
PIK3R2 (Bagci et al. 2020)
RACGAP1 (Amin et al. 2016: RHOD directed GAP activity; Bagci et al. 2020: no binding to active RHOD)

The following GAPs do not act on RHOD or were shown by Bagci et al. 2020 to not bind to active RHOD:
ABR (Amin et al. 2016; Bagci et al. 2020)
ARAP2 (Bagci et al. 2020)
ARAP3 (Bagci et al. 2020)
ARHGAP29 (Bagci et al. 2020)
ARHGAP31 (Bagci et al. 2020)
ARHGAP42 (Bagci et al. 2020)
BCR (Bagci et al. 2020)
DLC1 (Amin et al. 2016)
MYO9A (Bagci et al. 2020)
MYO9B (Bagci et al. 2020)
OPHN1 (Amin et al. 2016; Bagci et al. 2020)
SRGAP2 (Bagci et al. 2020)
STARD13 (Amin et al. 2016)
STARD8 (Amin et al. 2016)
SYDE1 (Bagci et al. 2020)