Reaction: HRSP12 deaminates 2AA to 2OBUTA
- in pathway: Threonine catabolism
The toxic enamine/imine intermediates generated by pyridoxal 5'-phosphate (PXLP) containing enzymes can cause severe cellular damage if allowed to accumulate (Downs & Ernst 2015). 2-iminobutanoate/2-iminopropanoate deaminase (RIDA aka HRSP12) is a widely conserved protein that prevents 2AA accumulation by facilitating its conversion to the stable metabolite 2-oxobutanoate (2OBUTA aka 2-ketobutyrate) (Cooper et al. 2011, Lambrecht et al. 2012, 2013, Niehaus et al. 2015).
Reaction - small molecule participants:
NH3 [cytosol]
2OBUTA [cytosol]
2AA [cytosol]
Reactome.org reaction link: R-HSA-9014641
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Reaction input - small molecules:
2-aminoacrylate
Reaction output - small molecules:
ammonia
2-oxobutanoic acid
Reactome.org link: R-HSA-9014641