Reaction: RHOQ GAPs stimulate RHOQ GTPase activity

- in pathway: RHOQ GTPase cycle
The following GTPase activating proteins (GAPs) were shown to bind RHOQ and stimulate its GTPase activity, resulting in GTP to GDP hydrolysis and conversion of the active RHOQ:GTP complex to the inactive RHOQ:GDP complex (the study by Bagci et al. 2020 examined binding of GAPs to constitutively active RHOQ mutant, without assessing RHOQ-directed GAP activity and is cited as supporting evidence):
ARHGAP1 (Amin et al. 2016; supported by Bagci et al. 2020)
ARHGAP26 (Amin et al. 2016)
DLC1 (Amin et al. 2016)

The following GAPs were shown to bind RHOQ and stimulate its GTPase activity in some but not all studies or were only shown by Bagci et al. 2020 to bind active RHOQ without testing for RHOQ-directed GAP activity and are annotated as candidate RHOQ GAPs:
ARHGAP5 (Bagci et al. 2020)
ARHGAP17 (Amin et al. 2016: RHOQ directed GAP activity; Bagci et al. 2020: no binding to active RHOQ)
ARHGAP21 (Bagci et al. 2020)
ARHGAP32 (Bagci et al. 2020)
ARHGAP35 (Amin et al. 2016: RHOQ directed GAP activity; Bagci et al. 2020: no binding to active RHOQ)
DEPDC1B (Bagci et al. 2020)
OPHN1 (Amin et al. 2016: RHOQ directed GAP activity; Bagci et al. 2020: no binding to active RHOQ)
SRGAP2 (Bagci et al. 2020)
SYDE1 (Bagci et al. 2020)

The following GAPs do not act on RHOQ or were shown by Bagci et al. 2020 to not bind to active RHOQ, without testing for their RHOQ-directed GAP activity:
ABR (Amin et al. 2016; Bagci et al. 2020)
ARAP2 (Bagci et al. 2020)
ARAP3 (Bagci et al. 2020)
ARHGAP12 (Bagci et al. 2020)
ARHGAP29 (Bagci et al. 2020)
ARHGAP31 (Bagci et al. 2020)
ARHGAP39 (Bagci et al. 2020)
ARHGAP42 (Bagci et al. 2020)
BCR (Bagci et al. 2020)
MYO9A (Bagci et al. 2020)
MYO9B (Bagci et al. 2020)
OCRL (Bagci et al. 2020)
RACGAP1 (Amin et al. 2016; Bagci et al. 2020)
STARD13 (Amin et al. 2016)
STARD8 (Amin et al. 2016)
Reaction - small molecule participants:
Pi [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-9018745

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Reaction input - small molecules:
water
ChEBI:15377
Reaction output - small molecules:
hydrogenphosphate
ChEBI:43474
Reactome.org link: R-HSA-9018745