Reaction: ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE
- in pathway: Biosynthesis of E-series 18(S)-resolvins
Unlike resolvin E3, which is biosynthesised in eosinophils or resident macrophages via the 15-lipoxygenase (ALOX15) pathway, resolvins E1 and E2 are biosynthesised by neutrophils via the 5-lipoxygenase pathway. In neutrophils, ALOX5 oxidises 18(S)-hydroxyeicosapentaenoic acid (18(S)-HEPE) to 5(S)-hydroperoxy-18(S)-hydroxyeicosapentaenoic acid (5(S)-Hp-18(S)-HEPE) (Tjonahen et al. 2006, Oh et al. 2012).
Reaction - small molecule participants:
5(S)-Hp-18(S)-HEPE [cytosol]
O2 [cytosol]
18(S)-HEPE [cytosol]
Reactome.org reaction link: R-HSA-9018858
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Reaction input - small molecules:
dioxygen
18(S)-HEPE
Reaction output - small molecules:
(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-icosapentaenoic acid
Reactome.org link: R-HSA-9018858