Reaction: ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE
- in pathway: Biosynthesis of E-series 18(S)-resolvins
In neutrophils, 5-lipoxygenase (ALOX5) can mediate the insertion of molecular oxygen into 5(S)-hydroperoxy-18(S)-hydroxyeicosapentaenoic acid (5(S)-Hp-18(S)-HEPE) to form 5S,6S-epoxy-18(S)-HEPE which is essential for 18(S)-resolvin E1 biosynthesis (Tjonahen et al. 2006, Oh et al. 2012).
Reaction - small molecule participants:
5S,6S-epoxy-18(S)-HEPE [cytosol]
O2 [cytosol]
5(S)-Hp-18(S)-HEPE [cytosol]
Reactome.org reaction link: R-HSA-9018859
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Reaction input - small molecules:
dioxygen
(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-icosapentaenoic acid
Reaction output - small molecules:
5(S)6-epoxy-18(S)-HEPE
Reactome.org link: R-HSA-9018859