Reaction: LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1
- in pathway: Biosynthesis of E-series 18(S)-resolvins
Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that uses a Zn2+ cofactor to catalyse the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) (McGee & Fitzpatrick 1985). LTA4H can also catalyse the hydrolysis of 5S,6S-epoxy-18(S)-HEPE to the 18(S) stereoisomer of resolvin E1 (18(S)-RvE1) (Oh et al. 2011). The E-resolvins are anti-inflammatory, pro-resolving, and non-phlogistic (that is, they mediate the clearance of leukocytes without eliciting an inflammatory response) (Serhan et al. 2008).
Reaction - small molecule participants:
18(S)-RvE1 [cytosol]
H2O [cytosol]
5S,6S-epoxy-18(S)-HEPE [cytosol]
Reactome.org reaction link: R-HSA-9018862
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Reaction input - small molecules:
water
5(S)6-epoxy-18(S)-HEPE
Reaction output - small molecules:
(18S)-resolvin E1
Reactome.org link: R-HSA-9018862