Reaction: ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE
- in pathway: Biosynthesis of E-series 18(R)-resolvins
In neutrophils, 5-lipoxygenase (ALOX5) can mediate the insertion of molecular oxygen into 5(S)-hydroperoxy-18(R)-hydroxyeicosapentaenoic acid (5(S)-Hp-18(R)-HEPE) to form 5S,6S-epoxy-18(R)-HEPE which is essential for 18(R)-resolvin E1 biosynthesis (Tjonahen et al. 2006, Oh et al. 2012).
Reaction - small molecule participants:
5S,6S-epoxy-18(R)-HEPE [cytosol]
5(S)-Hp-18(R)-HEPE [cytosol]
O2 [cytosol]
Reactome.org reaction link: R-HSA-9018894
======
Reaction input - small molecules:
5(S)-hydroperoxy-18(R)-hydroxy-(6E,8Z,11Z,14Z,16E)-icosapentaenoic acid
dioxygen
Reaction output - small molecules:
5S(6)-epoxy-18(R)-HEPE
Reactome.org link: R-HSA-9018894