Reaction: ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3
- in pathway: Biosynthesis of E-series 18(R)-resolvins
Unlike resolvins E1 and E2, both of which are biosynthesised by neutrophils via the 5-lipoxygenase pathway, resolvin E3 (RvE3) is biosynthesised in eosinophils or resident macrophages via the 15-lipoxygenase (ALOX15) pathway. 18(R)-hydroxyeicosapentaenoic acid (18(R)-HEPE) is oxidised by ALOX15 (possibly through C13-hydrogen abstraction) into a number of dihydroxy-HEPEs including 17(R),18(R)-diHEPE (18(R)-RvE3) (Isobe et al. 2012, Isobe et al. 2013).
Reaction - small molecule participants:
(18R)-resolvin E3 [cytosol]
18(R)-HEPE [cytosol]
O2 [cytosol]
Reactome.org reaction link: R-HSA-9018907
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Reaction input - small molecules:
18(R)-HEPE
dioxygen
Reaction output - small molecules:
(18R)-resolvin E3
Reactome.org link: R-HSA-9018907