Reaction: LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1
- in pathway: Biosynthesis of protectins
Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that uses a Zn2+ cofactor to catalyse the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) (McGee & Fitzpatrick 1985). LTA4H may also be able to catalyse the hydrolysis of 17R(6)-epoxy-docosahexaenoic acid (17R(16)-epoxy-DHA) to 10(R),17(R)-dihydroxydocosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid (aspirin-triggered (neuro)protectin D1, AT-(N)PD1) (Serhan et al. 2011). In human cells, AT-(N)PD1 decreased PMN migration as well as enhancing efferocytosis of apoptotic human PMN by macrophages, indicating AT-(N)PD1 as a potent anti-inflammatory proresolving molecule (Serhan et al. 2011).
Reaction - small molecule participants:
AT-(N)PD1 [cytosol]
H2O [cytosol]
17R(16)-epoxy-DHA [cytosol]
Reactome.org reaction link: R-HSA-9020257
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Reaction input - small molecules:
water
17R,(16)-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosahexa-4,7,10,13,15,19-enoic acid
Reaction output - small molecules:
aspirin-triggered protectin D1
Reactome.org link: R-HSA-9020257