Reaction: ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA
- in pathway: Biosynthesis of D-series resolvins
Lipoxygenase 5 (ALOX5) can oxidise 17(S)-hydroxydocosahexaenoic acid (17(S)-HDHA) into two hydroperoxy intermediates in human polymorphonuclear leukocytes (PMNs) (Serhan et al. 2002). The formation of 4(S)-hydroperoxy-17(S)-hydroxydocosahexaenoic acid (4(S)-Hp-17(S)-HDHA) is decribed here.
Reaction - small molecule participants:
4(S)-Hp-17(S)-HDHA [cytosol]
O2 [cytosol]
17(S)-HDHA [cytosol]
Reactome.org reaction link: R-HSA-9020264
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Reaction input - small molecules:
dioxygen
17(S)-HDoHE
Reaction output - small molecules:
4(S)-hydroperoxy-17(S)-hydroxydocosahexaenoic acid
Reactome.org link: R-HSA-9020264