Reaction: PRKCI phosphorylates ELF3
- in pathway: Pre-NOTCH Transcription and Translation
PRKCI (protein kinase C iota), activated in response to KRAS signaling, phosphorylates transcription factor ELF3 on serine residue S68. PRKCI-mediated phosphorylation of ELF3 promotes transcriptional activity of ELF3, probably by stimulating nuclear retention or import of ELF3 (Ali et al. 2016).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-9021357
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9021357