Reaction: HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1
- in pathway: Biosynthesis of E-series 18(S)-resolvins
In human blood, the major metabolic products of RvE1 are 10,11-dihydro-RvE1, 18-oxo-RvE1, and 20-hydroxy-RvE1 (Hong et al. 2008). 18-oxo-RvE1, formed by dimeric 15-hydroxyprostaglandin dehydrogenase (HPGD dimer) in the presence of NAD+, is also the major metabolite formed in murine lung and has been demonstrated to be devoid of activity, representing a mode of RvE1 inactivation (Arita et al. 2006). The exact enzymes that catalyze the formation of the other RvE1 metabolites mentioned here are currently unknown.
Reaction - small molecule participants:
18-oxo-RvE1 [cytosol]
NADH [cytosol]
18(S)-RvE1 [cytosol]
NAD+ [cytosol]
Reactome.org reaction link: R-HSA-9023968
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Reaction input - small molecules:
(18S)-resolvin E1
NAD(1-)
Reaction output - small molecules:
18-oxoresolvin E1
NADH(2-)
Reactome.org link: R-HSA-9023968