Reaction: Hydroperoxy reductase reduces 7(S)-Hp-17(R)-HDHA to AT-RvD5
- in pathway: Biosynthesis of aspirin-triggered D-series resolvins
An unknown reductase mediates the reduction of 7(S)-hydroperoxy-17(R)-hydroxydocosahexaenoic acid (7(S)-Hp-17(R)-HDHA) to AT-RvD5 (Serhan et al. 2002), the structure of which has been chemically synthesised as 7(S),17(R)-dihydroxydocosahexaenoic acid (Ogawa et al. 2017). In mice with E.coli infection, several specialized pro-resolving mediators (SPMs) including RvD5, together with antibiotics, accelerated resolution and heightened host antimicrobial responses (Chiang et al. 2012).
Reaction - small molecule participants:
AT-RvD5 [cytosol]
7(S)-Hp-17(R)-HDHA [cytosol]
Reactome.org reaction link: R-HSA-9024630
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Reaction input - small molecules:
7(S)-hydroperoxy-17(R)-hydroxydocosahexaenoic acid
Reaction output - small molecules:
aspirin-triggered resolvin D5
Reactome.org link: R-HSA-9024630