Reaction: HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1
- in pathway: Biosynthesis of D-series resolvins
Cytosolic, dimeric 15-hydroxyprostaglandin dehydrogenase (HPGD dimer), in the presence of NAD+, can oxidise 17(S)-resolvin D1 (RvD1) to the novel metabolites 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1. The 17(S)-oxo transformation effectively inactivates RvD1 activity whereas the 8-oxo metabolite retains most of its RvD1 activity (Sun et al. 2007). The epimeric 17(R) aspirin-triggered form (AT-RvD1) was also found to be able to resist rapid inactivation.
Reaction - small molecule participants:
NADH [cytosol]
RvD1 [cytosol]
NAD+ [cytosol]
Reactome.org reaction link: R-HSA-9024766
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Reaction input - small molecules:
resolvin D1
NAD(1-)
Reaction output - small molecules:
NADH(2-)
Reactome.org link: R-HSA-9024766