Reaction: LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1
- in pathway: Biosynthesis of protectins
Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that uses a Zn2+ cofactor to catalyse the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) (McGee & Fitzpatrick 1985). When produced in neural tissue, where it affords potent tissue protective actions, this docsanoid is called neuroprotectin D1 (NPD1).
Reaction - small molecule participants:
(N)PD1 [cytosol]
H2O [cytosol]
16S,17S-epoxy-DHA [cytosol]
Reactome.org reaction link: R-HSA-9024890
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Reaction input - small molecules:
water
(16S,17S)-epoxy-(4Z,7Z,10Z,12E,14E,19Z)-docosahexaenoic acid
Reaction output - small molecules:
protectin D1
Reactome.org link: R-HSA-9024890