Reaction: EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2
- in pathway: Biosynthesis of maresins
Dimeric bifunctional epoxide hydrolase 2 (EPHX2 dimer, soluble epoxide hydrolase, sEH) hydrolyses 13(S),14(S)-epoxy-docosahexaenoic acid (13(S),14(S)-epoxy-DHA) to form 13(R),14(S)-dihydroxy-docosahexaenoic acid, aka maresin 2 (MaR2) (Deng et al. 2014). Like MaR1, MaR2 possesses anti-inflammatory and pro-resolving activities although it is not as potent as MaR1 (Deng et al. 2014).
Reaction - small molecule participants:
MaR2 [cytosol]
H+ [cytosol]
13(S),14(S)-epoxy-DHA [cytosol]
Reactome.org reaction link: R-HSA-9024993
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Reaction input - small molecules:
hydron
(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid
Reaction output - small molecules:
(13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid
Reactome.org link: R-HSA-9024993