Reaction: ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA
- in pathway: Biosynthesis of maresins
In macrophages, lipoxygenase 5 (ALOX5) is proposed to further oxygenate 14(S)-hydroperoxy-docosahexaenoic acid (14(S)-Hp-DHA) to 7(S),14(S)-dihydroperoxy-docosaheaenoic acid (7(S),14(S)-diHp-DHA) (Serhan et al. 2009).
Reaction - small molecule participants:
7(S),14(S)-diHp-DHA [cytosol]
14(S)-Hp-DHA [cytosol]
O2 [cytosol]
Reactome.org reaction link: R-HSA-9024997
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Reaction input - small molecules:
(4Z,8E,10Z,12E,14S,16Z,19Z)-14-hydroperoxydocosahexaenoic acid
dioxygen
Reaction output - small molecules:
(7S,14S)-bis(hydroperoxy)-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoic acid
Reactome.org link: R-HSA-9024997