Reaction: Hydroperoxy reductase reduces 7(S),14(S)-diHp-DHA to 7-epi-MaR1
- in pathway: Biosynthesis of maresins
An unknown hydroperoxy reductase mediates the production of the double dioxygenation product 7(S),14(S)-hydroxy-docosa-4Z,8E,10Z,12E,16Z,19Z-hexaenoic acid (7(S),14(S)-HDHA aka 7-epi-MaR1) that proved to have less potent pro-resolving and anti-inflammatory activity than either maresin 1 (MaR1) or protectin D1 (PD1) (Serhan et al. 2009, Bannenberg & Serhan 2010).
Reaction - small molecule participants:
7-epi-MaR1 [cytosol]
7(S),14(S)-diHp-DHA [cytosol]
Reactome.org reaction link: R-HSA-9025007
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Reaction input - small molecules:
(7S,14S)-bis(hydroperoxy)-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoic acid
Reaction output - small molecules:
(7S,14S)-dihydroxy-(4Z,8E,10E,12Z,16Z,19Z)-docosahexaenoic acid
Reactome.org link: R-HSA-9025007