Reaction: ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6
- in pathway: Biosynthesis of DPAn-6 SPMs
The main product of ω-6 docosapentaenoic acid (DPAn-6) oxygenation by 12-lipoxygenase (ALOX12:Fe2+) is 14(S)-hydroxy-DPAn-6 (14(S)-HDPAn-6) (Dangi et al. 2009, 2010, Dobson et al. 2013). The final product is produced via a hydroperoxy intermediate, which is then reduced to the corresponding hydroxy compound (these details not described here and also, the human enzymes involved in these reactions are unknown). This DPAn-6 product is analogous in structure and action to DHA (docosahexaenoic acid)-derived resolvins (Dangi et al. 2010).
Reaction - small molecule participants:
14(S)-HDPAn-6 [cytosol]
DPAn-6 [cytosol]
O2 [cytosol]
Reactome.org reaction link: R-HSA-9025957
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Reaction input - small molecules:
(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid
dioxygen
Reaction output - small molecules:
(4Z,7Z,10Z,12E,14S,16Z)-14-hydroxydocosapentaenoic acid
Reactome.org link: R-HSA-9025957