Reaction: Hydroperoxy reductase reduces 7,17-diHp-DPAn-3 to RvD5n-3DPA
- in pathway: Biosynthesis of DPAn-3-derived protectins and resolvins
A hydroperoxy reductase probably reduces 7,17-dihydroperoxy-docosapentaenoic acid (7,17-diHp-DPAn-3) to the resolvin 7,17-dihydroxy-docosapentaenoic acid (RvD5n-3DPA) (Dalli et al. 2013). Treatment with RvD5n-3DPA reduced colitis and intestinal ischemia/reperfusion-induced inflammation in mice and reduced human neutrophil-endothelial cell interactions with TNF-α-activated human endothelial monolayers (Gobbetti et al. 2017). Although this is a proposed biosynthetic route for the formation of DPA-n-3 resolvins, it is assumed DPAn-3-derived SPMs follow a similar synthesis route to DHA- and EPA-derived SPMs.
Reaction - small molecule participants:
RvD5n-3DPA [cytosol]
7,17-diHp-DPAn-3 [cytosol]
Reactome.org reaction link: R-HSA-9026001
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Reaction input - small molecules:
(8E,10Z,13Z,15E,19Z)-7,17-bis(hydroperoxy)docosapentaenoic acid
Reaction output - small molecules:
7,17-dihydroxy-(8Z,15E,19Z)-docosa-8,10,13,15,19-pentaenoic acid
Reactome.org link: R-HSA-9026001