Reaction: ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3
- in pathway: Biosynthesis of DPAn-3-derived maresins
In a parallel pathway to 15-lipoxygenase-initiated protectin formation from ω-3 docosapentaenoic acid (DPAn-3), 12-lipoxygenase can also oxygenate DPAn-3 to form 14(S)-hydroperoxy-docosapentaenoic acid (14(S)-Hp-DPAn-3) (Dalli et al. 2013). This intermediate is the precursor for DPA-n-3-derived maresins.
Reaction - small molecule participants:
14(S)-Hp-DPAn-3 [cytosol]
DPAn-3 [cytosol]
O2 [cytosol]
Reactome.org reaction link: R-HSA-9026006
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Reaction input - small molecules:
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate
dioxygen
Reaction output - small molecules:
(7Z,10Z,12E,14S,16Z,19Z)-14-hydroperoxydocosapentaenoic acid
Reactome.org link: R-HSA-9026006