Reaction: Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA
- in pathway: Biosynthesis of DPAn-3-derived protectins and resolvins
In neutrophils, an epoxide hydrolase is thought to hydrolyse 7,8-epoxy-17-hydroxydocosapentaenoic acid (7,8-epoxy-HDPAn-3) to either of the resolvins 7,8,17-trihydroxy-docosapentaenoic acid (RvD1n-3DPA) or 7,16,17-trihydroxy-docosapentaenoic acid (RvD2n-3DPA) (Dalli et al. 2013). Treatment of induced inflammation in mice with RvD1n-3DPA and RvD2n-3DPA reduced neutrophil infiltration and adhesion and enhanced macrophage phagocytosis; all key steps in inflammatory resolution (Dalli et al. 2013, Gobbetti et al. 2017). Although this is a proposed biosynthetic route for the formation of DPA-n-3 resolvins, it is assumed DPAn-3-derived SPMs follow a similar synthesis route to DHA- and EPA-derived SPMs.
Reaction - small molecule participants:
H2O [cytosol]
7,8-epoxy,17-HDPAn-3 [cytosol]
Reactome.org reaction link: R-HSA-9026008
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Reaction input - small molecules:
water
7,8-epoxy,17-hydroxy-(9E,11E,13Z,15E,19Z)-docosapentaenoic acid
Reaction output - small molecules:
Reactome.org link: R-HSA-9026008