Reaction: ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4
- in pathway: Biosynthesis of DPAn-3-derived 13-series resolvins
In neutrophils, 5-lipoxygenase (ALOX5) oxidises 13(R)-hydroxy-docosapentaenoic acid (13(R)-DPAn-3) to the 13(R)-resolvins RvT1-4 (7,13,20-trihydroxy-docosapentaenoic acid, 7,12,13-trihydroxy-docosapentaenoic acid, 7,8,13-trihydroxy-docosapentaenoic acid and 7,13-dihydroxy-docosapentaenoic acid respectively) (Dalli et al. 2015, Primdahl et al. 2016). They were all shown to posses anti-inflammatory and proresolving activities (Dalli et al. 2015). Recently, RvTs have been shown to mediate the proresolving actions of several statins in mice with inflammatory arthritis (Walker et al. 2017).
Reaction - small molecule participants:
13(R)-HDPAn-3 [cytosol]
O2 [cytosol]
Reactome.org reaction link: R-HSA-9026405
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Reaction input - small molecules:
(7Z,10Z,13R,14E,16Z,19Z)-13-hydroxydocosapentaenoate
dioxygen
Reaction output - small molecules:
Reactome.org link: R-HSA-9026405