Reaction: PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3
- in pathway: Biosynthesis of DPAn-3 SPMs
Incubation of ω-3 docosapentaenoic acid (DPAn-3) with human recombinant cyclooxygenase 2 (PTGS2 dimer, COX2) in vascular endothelial cells produces 13(R)-hydroxy-docasapentaenoic acid (13(R)-HDPAn-3), the precursor of 13(R)-resolvins and the electrophilic 13-oxo-DPAn-3 (Dalli et al. 2015, Primdahl et al. 2016).
Reaction - small molecule participants:
13(R)-HDPAn-3 [cytosol]
DPAn-3 [cytosol]
O2 [cytosol]
Reactome.org reaction link: R-HSA-9026408
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Reaction input - small molecules:
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate
dioxygen
Reaction output - small molecules:
(7Z,10Z,13R,14E,16Z,19Z)-13-hydroxydocosapentaenoate
Reactome.org link: R-HSA-9026408