Reaction: GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1
Cytosolic, dimeric glutathione S-transferase Mu 4 (GSTM4 dimer) can catalyse the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid (13(S),14(S)-epoxy-DHA) to form maresin conjugate in tissue regeneration 1 (MCTR1) (Dalli et al. 2014, 2016a, 2016b). MCTR1, given to mice with E. coli peritonitis, showed potent proresolving action in inflammation and infections. With human macrophages, MCTR1 stimulated efferocytosis of apoptotic cells (Dalli et al. 2014).
Reaction - small molecule participants:
MCTR1 [cytosol]
GSH [cytosol]
13(S),14(S)-epoxy-DHA [cytosol]
Reactome.org reaction link: R-HSA-9026777
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Reaction input - small molecules:
glutathionate(1-)
(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid
Reaction output - small molecules:
(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid
Reactome.org link: R-HSA-9026777