Reaction: NTRK2 phosphorylates SHC1
- in pathway: Activated NTRK2 signals through RAS
Activated NTRK2 (TRKB) phosphorylates SHC1-2 (SHC1 p52) isoform at tyrosine residue Y317. This tyrosine residue corresponds to Y272 of SHC1-3 (SHC1 p46) isoform (Chan et al. 2011).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9026890
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9026890