Reaction: GGT hydrolyses PCTR2 to PCTR3
- in pathway: Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)
In human macrophages, protectin conjugate in tissue regeneration 3 (PCTR2) is proposed to be hydrolysed to PCTR3 (16-cysteinyl, 17-hydroxy-docosahexaenoic acid) by the actions of a glutathione transferase (GGT). Human macrophages incubated with E. coli and a GGT inhibitor led to increased levels of PCTR1 and decreased levels of PCTR3, suggesting a role for GGT enzyme in PCTR2 and PCTR3 biosynthesis (Dalli et al. 2015).
Reaction - small molecule participants:
PCTR3 [cytosol]
Gly [cytosol]
H2O [cytosol]
PCTR2 [cytosol]
Reactome.org reaction link: R-HSA-9026907
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Reaction input - small molecules:
water
16(S)-glycinylcystein-S-yl-17(R)-hydroxy-(4Z,7Z,10,12,14,19Z)-docosahexaenoic acid
Reaction output - small molecules:
16(S)-cystein-S-yl,17(R)-hydroxy-(4Z,7Z,10,12,14,19Z)-docosahexaenoic acid
glycine zwitterion
Reactome.org link: R-HSA-9026907