Reaction: LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1
- in pathway: Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)
Just as the addition of glutathione (GSH) to an allylic epoxide is governed by glutathione S-transferase enzymes in the biosynthesis of MCTR (Dalli et al. 2016), 7S(8)-epoxy-17(S)-hydroxy-docosahexaenoic acid (7S(8)-epoxy-17(S)-HDHA) may presumably be conjugated with GSH by trimeric leukotriene C4 synthase (LTC4S trimer) to form resolvin conjugate in tissue regeneration 1 (RCTR1, 8-glutathionyl, 7,17-dihydroxy-docosahexaenoic acid) (Dalli et al. 2015).
Reaction - small molecule participants:
RCTR1 [cytosol]
GSH [cytosol]
7S(8)-epoxy-17(S)-HDHA [cytosol]
Reactome.org reaction link: R-HSA-9026911
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Reaction input - small molecules:
glutathionate(1-)
7S(8)-epoxy-17(S)-hydroxydocosahexaenoic acid
Reaction output - small molecules:
(8S)-glutathionyl-(7R,17S)-dihydroxy-(4Z,9,11,13Z,15E,19Z)-docosahexaenoic acid
Reactome.org link: R-HSA-9026911