Reaction: GGT hydrolyses PCTR1 to PCTR2
- in pathway: Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)
In human macrophages, protectin conjugate in tissue regeneration 1 (PCTR1) is proposed to be hydrolysed to PCTR2 (16-cysteinylglycinyl, 17-hydroxy-docosahexaenoic acid) by the actions of a glutathione transferase (GGT). Human macrophages incubated with E. coli and a GGT inhibitor led to increased levels of PCTR1 and decreased levels of PCTR3, suggesting a role for GGT enzyme in PCTR2 and PCTR3 biosynthesis (Dalli et al. 2015).
Reaction - small molecule participants:
L-Glu [cytosol]
PCTR2 [cytosol]
PCTR1 [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-9026912
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Reaction input - small molecules:
16(S)-glutathionyl-17(R)-hydroxy-(4Z,7Z,10,12,14,19Z)-docosahexaenoic acid
water
Reaction output - small molecules:
L-glutamate(1-)
16(S)-glycinylcystein-S-yl-17(R)-hydroxy-(4Z,7Z,10,12,14,19Z)-docosahexaenoic acid
Reactome.org link: R-HSA-9026912