Reaction: GGT hydrolyses RCTR2 to RCTR3
- in pathway: Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)
Presumably following a similar synthesis route to protectin conjugate in tissue regeneration 3 (PCTR3), resolvin conjugate in tissue regeneration 2 (RCTR2) could be hydrolysed to RCTR3 (8-cysteinyl, 7,17-dihydroxy-docosahexaenoic acid) by the actions of a glutathione transferase (GGT) (Dalli et al. 2015).
Reaction - small molecule participants:
RCTR3 [cytosol]
Gly [cytosol]
H2O [cytosol]
RCTR2 [cytosol]
Reactome.org reaction link: R-HSA-9026916
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Reaction input - small molecules:
water
(8S)-glycinylcystein-S-yl-(7R,17S)-dihydroxy-(4Z,9,11,13Z,15E,19Z)-docosahexaenoic acid
Reaction output - small molecules:
(8S)-cystein-S-yl-(7R,17S)-dihydroxy-(4Z,9,11,13Z,15E,19Z)-docosahexaenoic acid
glycine zwitterion
Reactome.org link: R-HSA-9026916